Degradation and Drug Release Characteristics of Monosize Polyethylcyanoacrylate Microspheres

ÇIÇEK H., TUNCEL A., TUNCEL M., PIPKIN E.

Journal of Biomaterials Science, Polymer Edition, vol.6, no.9, pp.845-856, 1995 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 9
  • Publication Date: 1995
  • Doi Number: 10.1163/156856295x00238
  • Journal Name: Journal of Biomaterials Science, Polymer Edition
  • Journal Indexes: Scopus
  • Page Numbers: pp.845-856
  • Keywords: biodegradable microspheres, Biodegradation, drug release, ethyl- cyanoacrylate, nanoparticles, polyalkylcyanoacrylate
  • Lokman Hekim University Affiliated: No

Abstract

Monosize, biodegradable poly(ethylcyanoacrylate) (PECA) microspheres with a diameter of 3 µm were prepared by a relatively new polymerization method, the so-called phase inversion polymerization. The effects of pH and temperature on the degradation behavior of PECA particles were investigated. PECA microspheres were degraded mainly by surface erosion. The degradation rate increased with increasing pH temperature. A model drug, i.e. 2,4-dinitrophenylhydrazine (DNPH) was loaded into the monosize PECA microspheres during polymerization. The drug incorporation into the PECA microspheres increased with increasing initial drug concentration in the monomer phase. Drug release from the PECA microspheres was investigated at different pH. Higher drug release rates were observed in the neutral and alkaline media as compared with the acidic medium. © 1995, VSP. All rights reserved.