Akademik Veri Yönetim Sistemi
Turkish Journal of Biochemistry, 2026 (SCI-Expanded, Scopus, TRDizin)
Objectives: This study aimed to evaluate the effects of monosodium glutamate (MSG) exposure during the childhood-equivalent period on learning, memory, and neurobehaviour, considering potential sex-related differences. Methods: Sixty-six post-weaning Wistar Albino rats were randomly assigned to Control (C), Low Dose (LD; 25 mg/kg/ day), and High Dose (HD; 2,500 mg/kg/day) groups for 6 weeks. Behavioral assessments included the Morris Water Maze (MWM), Open Field Test (OFT), and Forced Swim Test (FST). Following behavioral testing, hippocampal tissues were collected to measure NR2A, NR2B, nAChR α7, and 5-HT2A receptor levels. Results: While all groups improved spatial learning over time, the HD group showed a delayed learning curve. In the OFT, HD rats exhibited reduced exploratory activity, suggesting anxiety-like behavior. In the FST, both LD and HD groups had increased immobility durations, indicating behavioral despair. Receptor analysis revealed significantly increased NR2A expression in