Simultaneous determination of caffeine and chlorphenoxamine hydrochloride in mixture by first derivative spectrophotometry

DİNÇ E., ONUR F.

Gazi Universitesi Eczacilik Fakultesi Dergisi, cilt.12, sa.1, ss.63-72, 1995 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 1995
  • Dergi Adı: Gazi Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.63-72
  • Anahtar Kelimeler: caffeine, chlorphenoxamine hydrochloride, derivative spectrophotometry, pharmaceutical preparation
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Rapid first derivative spectrophotometric determination of caffeine and chlorphenoxamine hydrochloride in their binary mixture was described. The method has been succesfully applied to a sugar-coated tablet marketing in Turkey and containing caffeine and chlorphenoxamine hydrochloride. Derivative molar absorbancy values were calculated at 230.1 nm and 259.2 nm and the quantitation of caffeine and chlorphenoxamine hydrochloride has been realized by solving simultaneously the equations with two unknown. The relative standard deviation of the method was found to be % 1.43 and % 1.01 for caffeine and chlorphenoxamine hydrochloride respectively.