Cotinus coggygria Scop. extract-loaded polycaprolactone/hyaluronic acid nanofibers as candidate wound dressings: in vitro characterization, cytocompatibility and antibacterial evaluation
FRONTIERS IN PHARMACOLOGY, cilt.17, sa.2026, ss.1-19, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 2026
- Basım Tarihi: 2026
- Doi Numarası: 10.3389/fphar.2026.1948812
- Dergi Adı: FRONTIERS IN PHARMACOLOGY
- Derginin Tarandığı İndeksler: Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Scopus, Science Citation Index Expanded (SCI-EXPANDED), BIOSIS, EMBASE, Directory of Open Access Journals
- Sayfa Sayıları: ss.1-19
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Lokman Hekim Üniversitesi Adresli: Evet
Özet
Cotinus coggygria Scop. (Anacardiaceae) possesses antibacterial, antioxidant, anticancer, and wound-healing properties. Hyaluronic acid (HA), a key extracellular matrix component, supports tissue regeneration. In this study, electrospun polycaprolactone (PCL) nanofibers containing C. coggygria extract and HA were developed as wound dressings. Optimized polymer solutions and electrospinning parameters were used according to material composition. Nanofibers were characterized by contact angle measurements, texture analysis, scanning electron microscopy, and in vitro cell culture assays. The fiber diameters ranged from 300 to 700 nm, and contact angle decreased to 65.3°, indicating improved hydrophilicity due to HA and C. coggygria extract incorporation. The addition of extract and HA yielded a maximum tensile strength of 2.40 MPa. After 24 h of exposure, the F5 maintained L929 fibroblast viability above 80% across the entire tested range (0.062–1 mg/mL). At 48 h, F5 produced the lowest apoptotic (6% ± 1%) and necrotic (10% ± 1%) indices among the extract-containing fibers at 1 mg/mL, indicating cytocompatibility towards L929 fibroblasts under the conditions tested. Antibacterial tests revealed inhibition zones of 21 ± 0 mm against Staphylococcus aureus and 6 ± 1 mm against Escherichia coli. Overall, PCL nanofibers incorporating C. coggygria extract and HA demonstrate promising potential for wound healing applications owing to their favorable mechanical properties, high biocompatibility, and notable antibacterial activity.