Day-case laparoscopy: A comparison of prophylactic opioid, NSAID or local anesthesia for postoperative analgesia

Salman M. A., Yücebaş M. E., COŞKUN F. M., AYPAR Ü.

Acta Anaesthesiologica Scandinavica, vol.44, no.5, pp.536-542, 2000 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 5
  • Publication Date: 2000
  • Doi Number: 10.1034/j.1399-6576.2000.00508.x
  • Journal Name: Acta Anaesthesiologica Scandinavica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.536-542
  • Keywords: Analgesics, opioid, fentanyl, Anesthetics, local, bupivacaine, Anti-inflammatory agents, non- steroidal, tenoxicam, Pain, postoperative, Surgery, outpatient, Surgical procedures, laparoscopic
  • Lokman Hekim University Affiliated: Yes


Background: The study was aimed to evaluate the analgesic efficacy, postoperative comfort, recovery characteristics and side effects of three different analgesic agents administered prophylactically. Methods: Eighty patients undergoing day-case minor operative laparoscopy were randomly allocated into four groups to receive tenoxicam 20 mg i.v. (Group T), fentanyl 100 μg i.v. (Group F), 5 ml of bupivacaine 2.5 mg/ml for infiltration of trocar sites (Group B), 30, 10 and 5 min before incision respectively. Bupivacaine, 35 ml, 2.5 mg/ml was also administered into the pelvic cavity in Group B. Group P received only placebo. Postoperative pain, analgesic requirements, first response to verbal stimulus, first analgesic requirement, ability to walk without help, to drink and to void, blood pressures, SpO2 and respiration rates were recorded in the PACU. Postoperative pain was evaluated by verbal rating scale. Pain scores, analgesic requirements and side effects were evaluated by telephone calls until the 48th postoperative hour. Results: Postoperative pain scores were lower and time to requirement of rescue analgesics was longer in groups F and B compared to Group E In the PACU, analgesic requirements were lower in Group B, compared to Group P. Nausea and vomiting were increased in Group E Conclusion: Tenoxicam 20 mg i.v. was found to be ineffective whereas bupivacaine was superior to other groups in reducing pain and analgesic requirements. Bupivacaine also increased time to first analgesics and obtained better recovery characteristics, underlining its value in prophylactic pain management compared to the other two agents. (C) Acta Anaesthesiologica Scandinavica 44 (2000).