Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide

Demirel F., ÜNAL S., Çetin I. I., Esen I., Arasli A.

Journal of Pediatric Endocrinology and Metabolism, vol.24, no.7-8, pp.603-605, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 7-8
  • Publication Date: 2011
  • Doi Number: 10.1515/jpem.2011.238
  • Journal Name: Journal of Pediatric Endocrinology and Metabolism
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.603-605
  • Keywords: diazoxide, ductus arteriosus, pulmonary hypertension, toxic effect, PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA, SMOOTH-MUSCLE-CELLS, HETEROGENEITY, DIAGNOSIS, CHANNEL
  • Lokman Hekim University Affiliated: No


Diazoxide is the main therapeutic agent for persistent hyperinsulinemic hypoglycemia. Generally, it is tolerated well, but rarely it can cause severe life-threatening complications. We report a neonate who was treated with diazoxide for hyperinsulinemic hypoglycemia. On the 6th day of the treatment we observed sepsis-mimicking symptoms, mild pulmonary hypertension, and re-opening of the ductus arteriosus. All these findings resolved dramatically shortly after discontinuation of treatment. To our knowledge, this is the first reported case of re-opening of the ductus arteriosus due to diazoxide toxicity. © 2011 by Walter de Gruyter Berlin Boston.