ASSESSMENT OF DISEASE ACITIVITY IN MULTIPLE SCLEROSIS VIA FETUIN-A LEVELS


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Mühürdaroğlu M., Eruyar E., Kılınckaya M. F., Bilen S., Oztekin N.

İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi, vol.27, no.2, pp.158-164, 2023 (Peer-Reviewed Journal) identifier

Abstract

Introduction: Fetuin-A is a glycoprotein found to be elevated in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS). Examination of fetuin-A in MS may contribute to the our understanding of MS pathophysiology. We aimed to examine CSF and serum levels of fetuin-A in MS patients, and to assess relationships with disease activity. Materials and Methods: Twenty-two patients, classified as definite MS (n = 15) and clinically isolated syndrome (CIS, n = 7), and 27 age- and sex-matched cases with pseudotumor cerebri were included in the study. The ELISA method was used to determine fetuin-A levels in the CSF samples of the patient and control groups. Results: The patient and control groups were similar in terms of sex distribution, but mean age was significantly lower in patients (31.5 vs. 39.3 years, p>0.05).While patients and controls had similar fetuin-A levels at baseline and on the 6th month, CSF fetuin-A levels were significantly higher in patients with MS (p=0.01) compared to those with CIS.Patients with active and inactive disease had similar fetuin-A levelsin all comparisons, but patients with active disease appeared to have some what higher fetuin-A compared to those with inactive disease. Conclusion: To conclude, our findings showed that patients with MS and controls had similar fetuin-A levels (serum and CSF). However, at baseline, patients with MS had significantly higher fetuin-A concentrations compared to those with CIS. Fetuin-A levels were not si gnificantly associated with disease activity, but patients with active disease seemed to have relatively higher levels than those with inactive disease.