The effect of inhalation anesthetics on serum melatonin levels ̇Inhalasyon anesteż ikleṙ iṅ in serum melatoṅ in düzeyleṙine etk̇iṡ i

Karagöz H., Başgül E., Çeliker V., AYPAR Ü.

Anestezi Dergisi, vol.12, no.1, pp.33-36, 2004 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 1
  • Publication Date: 2004
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.33-36
  • Keywords: Halothane, Isoflurane, Melatonin, Sevoflurane
  • Lokman Hekim University Affiliated: Yes


The pineal hormone melatonin and anesthetic agents affect sleep and behaviour. We aimed to compare the effects of halothane, isoflurane and sevoflurane on endogen melatonin levels in 46 patients scheduled for laparoscopic cholecystectomy. Patients were randomly assigned to three groups. General anesthesia was induced with thiopentone/vecuronium/fentanyl. In the first group, anesthesia was achieved with halothane (Group H, n=16), in the second group with isoflurane (Group I, n=15) and in the third group with sevoflurane (Group S, n=15) in N2O / O2 in all groups. During anesthesia, the patients' eyes were carefully taped to prevent the effects of light. To detect the melatonin levels, blood samples were taken at 0200 a.m., before induction, 15 minutes after induction, and just after extubation. In our study similar to the circadian rhythm of melatonin, plasma melatonin level ecreased, and remained at the same level after extubation. There were no differences in circulatory melatonin levels among the groups. We concluded that, these three anesthetic agents used in our study did not effect the level of melatonin and there were no differences in circulatory melatonin levels among the groups.