Ovulation induction with gonadotropins causes increased sister chromatid exchanges


Tonguç E., CEYLANER G., Var T., Zülfikaroǧlu E., CEYLANER S.

Genetic Counseling, vol.22, no.2, pp.193-198, 2011 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 2011
  • Journal Name: Genetic Counseling
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.193-198
  • Keywords: Gonadotropins, Sister Chromatid Exchange (SCE), Ovarian cancer, Reproductive hormones, Estradiol, IN-VITRO FERTILIZATION, CHROMOSOME-ABERRATIONS, INFERTILE WOMEN, OVARIAN-TUMORS, CANCER, LYMPHOCYTES, FREQUENCY, COHORT, RISK, ESTROGEN

Abstract

Gonadotropins are widely accepted agents for ovulation induction in infertile women. On the other hand, several authors discuss the possible effect of gonadotropins on the developmental mechanism of ovarian cancer. SCE is a method of genotoxicity investigation and it is an excellent parameter to monitor the DNA damage and repair. There are numbers of studies showing the relationship between endogenous or exogenous hormones and SCEs. The aim of this study was to investigate with SCE techniques the effects of long-term (6 months) use of gonadotropins on DNA as we couldn't find any other study on the effect of long term use. We found increased sister chromatid exchange rates in a study group as compared to a control group. This may be one of the causes of increased ovarian cancer risk in infertile population.