Chronic bullous disease of childhood in a patient with acute lymphoblastic leukemia: Possible induction by a drug

Polat M., Lenk N., Kürekçi E., Öztaş P., Artüz F., Alli N.

American Journal of Clinical Dermatology, vol.8, no.6, pp.389-391, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 6
  • Publication Date: 2007
  • Doi Number: 10.2165/00128071-200708060-00010
  • Journal Name: American Journal of Clinical Dermatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.389-391
  • Keywords: Autoimmune disorders, general, Children, Cotrimoxazole, therapeutic use, Leukaemia, general
  • Lokman Hekim University Affiliated: No


Linear IgA disease is characterized by the presence of linear IgA deposits in the basement membrane zone of the skin, and circulating basement membrane zone antibodies are detected in 80% of cases. The disease occurs in both adults and children, and is designated adult linear IgA disease in the former and chronic bullous disease of childhood (CBDC) in the latter. We describe a 5-year-old boy with acute lymphoblastic leukemia in remission, in whom CBDC developed after treatment with trimethoprim/sulfamethoxazole (cotrimoxazole). To our knowledge, this is the first reported case of possible drug-induced CBDC. © 2007 Adis Data Information BV. All rights reserved.