Antimycobacterial properties of some 2,5-disubstituted-benzoxazole derivatives


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ARISOY M., ARPACI Ö., Kaynak-Onurdag F., Ozgen S.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.39, no.2, pp.155-162, 2010 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1501/eczfak_0000000561
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus
  • Page Numbers: pp.155-162
  • Keywords: Antimycobacterial activity, Benzoxazoles, Mycobacterium tuberculosis

Abstract

A set of 2-(p-substituted-benzyl)-5-[[4-(p-chloro/fluoro-phenyl)piperazin- 1-yl]acetamido]-benzoxazoles was evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis and its isolate in comparison with reference drugs. The activity was expressed as minimum inhibitory concentration (MIC) in μg/ml. Compounds showed similar activity against test strains and most of them were more potent against M. tuberculosis than its isolate. Compound 9 exhibited a MIC value of 8 μg/ml against both of the tested microorganisms and had the highest activity among all derivatives. This microbiological assay showed that these benzoxazole derivatives possess a broad spectrum of antimycobacterial activity having MIC values of 8-64 μg/ml against the tested strains.