Expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma

Erbek S., Erinanc H., Hizal E., Ozluoglu L.

Journal of Laryngology and Otology, cilt.127, sa.2, ss.153-158, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 127 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1017/s0022215112003106
  • Dergi Adı: Journal of Laryngology and Otology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.153-158
  • Anahtar Kelimeler: ADAM proteins, ADAM-10 protein, human, ADAM12 protein, human, ADAM17 protein, human, Cholesteatoma
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Objective: Proteases of the disintegrin and metalloproteinase family (also known as ADAM proteins) are involved in various physiological and pathological processes. This study assessed the expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma. Materials and methods: The study evaluated cholesteatoma specimens from 19 patients, and external ear canal skin samples from 7 of the same patients (as controls), for the expression of disintegrin and metalloproteinase family proteins 10, 12 and 17, using immunohistochemical methods. Results and analysis: The study observed over-expression of proteins 10 and 17 in blood vessels, and over-expression of proteins 12 and 17 in cholesteatoma stroma. Immunostaining scores for proteins 10, 12 and 17 in epithelial and inflammatory cells from cholesteatoma specimens versus control specimens showed no statistically significant differences. Conclusion: Over-expression of disintegrin and metalloproteinase family proteins 10, 12 and 17 in cholesteatoma may be related to cholesteatoma pathogenesis. These proteins deserve further study as they may represent potential targets for cholesteatoma treatment. © 2012 JLO (1984) Limited.