Synthesis and microbiological activity of 5-methyl-2-[p-substituted phenyl]benzoxazoles

YALÇIN İ., Şener E., Özden T., ÖZDEN M. S., Akin A.

European Journal of Medicinal Chemistry, vol.25, no.8, pp.705-708, 1990 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 8
  • Publication Date: 1990
  • Doi Number: 10.1016/0223-5234(90)90137-r
  • Journal Name: European Journal of Medicinal Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.705-708
  • Keywords: 2,5-disubstituted benzoxazoles, anti-microbiological activity
  • Lokman Hekim University Affiliated: No


The synthesis and microbiological activity of a series of 5-methyl-2-(p-substituted phenyl)benzoxazoles 7a-7g are described. The in vitro microbiological activity of these compounds was determined against some Gram-positive and Gram-negative bacteria and C albicans. The observed minimum inhibitory concentration (MIC) values of the derivatives were compared to some other 2,5-disubstituted benzoxazoles and clinically used drugs. The in vitro microbiological data showed that the derivatives 7a-7g exhibited a broad spectrum of antibacterial activity and 7a-c and 7g were significantly active against E coli and/or K pneumoniae at an MIC of 6.2 μg/ml. © 1990.