Synthesis and microbiological activity of 5-methyl-2-[p-substituted phenyl]benzoxazoles

YALÇIN İ., Şener E., Özden T., ÖZDEN M. S., Akin A.

European Journal of Medicinal Chemistry, cilt.25, sa.8, ss.705-708, 1990 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 8
  • Basım Tarihi: 1990
  • Doi Numarası: 10.1016/0223-5234(90)90137-r
  • Dergi Adı: European Journal of Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.705-708
  • Anahtar Kelimeler: 2,5-disubstituted benzoxazoles, anti-microbiological activity
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The synthesis and microbiological activity of a series of 5-methyl-2-(p-substituted phenyl)benzoxazoles 7a-7g are described. The in vitro microbiological activity of these compounds was determined against some Gram-positive and Gram-negative bacteria and C albicans. The observed minimum inhibitory concentration (MIC) values of the derivatives were compared to some other 2,5-disubstituted benzoxazoles and clinically used drugs. The in vitro microbiological data showed that the derivatives 7a-7g exhibited a broad spectrum of antibacterial activity and 7a-c and 7g were significantly active against E coli and/or K pneumoniae at an MIC of 6.2 μg/ml. © 1990.