New class of steroidal alkaloids from Fritillaria imperialis

Akhtar M., Atta-ur-Rahman A., Choudhary M., Sener B., Erdogan İ., Tsuda Y.

Phytochemistry, vol.63, no.1, pp.115-122, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1016/s0031-9422(02)00569-1
  • Journal Name: Phytochemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.115-122
  • Keywords: Fritillaria imperialis, impranine, dihydroimpranine, fetisinine, impranane-type steroidal alkaloids
  • Lokman Hekim University Affiliated: No

Abstract

Two members of a new class of C-nor-D-homo steroidal alkaloids, impranine (1) and dihydroimpranine (2) along with a new pyridyl-pregnane-type steroidal alkaloid, fetisinine (3) and a known base, korsevine (4) were isolated from the bulbs of Fritillaria imperialis. The structures of the compounds were established on the basis of spectroscopic techniques and some chemical transformations. Compounds 1 and 2 form a new class of steroidal alkaloids, named as "impranane." © 2003 Elsevier Science Ltd. All rights reserved.