Investigation of association between slime production by Candida Spp and susceptibility to fluconazole and voriconazole

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KAŞKATEPE B., YILDIZ S.

Tropical Journal of Pharmaceutical Research, vol.12, no.5, pp.821-825, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.4314/tjpr.v12i5.24
  • Journal Name: Tropical Journal of Pharmaceutical Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.821-825
  • Keywords: Candida, Fluconazole, Voriconazole, Antifungal susceptibility, Slime, BIOFILM PRODUCTION
  • Lokman Hekim University Affiliated: No

Abstract

Purpose: To determine the susceptibilities of fluconazole and voriconazole based on slime production by Candida spp. Methods: Candida strains (115) isolated in the period between January 2011 and January 2012 were included in this study. Conventional methods were used for the identification. Candida albicans and non-C. albicans isolates were tested for slime production with modified tube adherence test and antifungal resistance with disk diffusion method. Results: Slime positivity was 31.3% in all Candida species. Slime positivity in non-C.albicans isolates (44.89%) was higher than in C. albicans species (21.21%). All C. albicans isolates were sensitive to fluconazole and voriconazole. The highest resistance to fluconazole (40%) and voriconazole (5%) was by C. glabrata strains. Conclusion: Species definition and determination of antifungal susceptibility patterns are advised for the proper management and treatment of patients. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.