Purpose: To evaluate the outcomes of 23 gauge (G) pars plana vitrectomy (PPV) in cases of acute endophthalmitis developing after cataract surgery. Materials and Methods: The medical records of cases who were performed 23 G PPV for acute endophthalmitis which occured after cataract surgery are evaluated retrospectively. The clinical features, visual acuity and the complications were noted. Results: Twenty-one postoperative acute endophthalmitis cases with a mean age of 71.4 (48-84) years were included in this study. All cases were performed 23 G PPV with intraocular antibiotic injection regardless of initial visual acuity. The mean follow-up time was 12.9 (6-36 months). Culture results were achived as positive only in 5 (23.8%) cases. The presenting visual acuity was hand motion, light perception and projection or worse in all cases. In 6 (28.6%) cases second vitrectomy surgery was performed after 72 hours because of ineffcient results. Retinal detachment surgery with silicone oil was performed in one case because of postoperative retinal detachment. In one case infammation was not controlled and evisceration was performed. At the fnal follow-up visit the visual acuity was between counting fngers and 0.05 in 14 cases (66.7%), and between 0.1 and better in 6 cases (28.6%). Conclusion: In our cases with acute endophthalmitis that developed after cataract surgery, we determine that 23 G su-tureless PPV performed as an initial treatment was safe and effective in increasing the visual acuity. Further studies with longer follow-up periods are needed to evaluate the safety and the effectiveness of the procedure.