Antibiotic resistance rates of Shigella species isolated from stool cultures in the years 1999-2003 Dιşkι kültürlerinden 1999-2003 yιllarι arasιnda izole edilen Shigella türleri ve antibiyotiklere direnç oranlarι


Alici Ö., Açikgöz Z. C. , Gamberzade Ş., Göçer S., Karahocagil M. K.

Mikrobiyoloji Bulteni, vol.40, no.1-2, pp.9-14, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 1-2
  • Publication Date: 2006
  • Journal Name: Mikrobiyoloji Bulteni
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.9-14
  • Keywords: Antibiotic resistance, Shigella, Stool cultures
  • Lokman Hekim University Affiliated: Yes

Abstract

In this study, species distribution, seasonal isolation rates and antibiotic susceptibilitiy patterns of 115 Shigella spp, isolated from 5396 stool samples in our microbiology laboratory between 1999 and 2003, were investigated. Of the isolates, 96 (83.5%) were S.sonnei, 15 (13%) were S. flexneri, 3 (2.6%) were S. dysenteriae and 1 (1.9%) was S.boydii. Maximum isolation rates were observed at summer and fall seasons, especially in August, September and November (24%, 40%, 17%, respectively). The resistance rates aginst trimetoprime-sulphametoxasole and ampicillin were 79.1% and 19.1%, respectively. The rate of co-resistance against these two drugs was 12.2 percent. No isolate was found to be resistant to ciprofloxacin. Only one S. sonnei isolate had extended spectrum beta-lactamase detected by double-disk synergy test. In conclusion, ciprofloxacin is the drug of choice for empirical treatment of shigellosis. However, to avoid the loss of this choice, ampicillin which still has an high effectivity rate, should be preferred for the treatment of shigellosis with the guidence of antibiogram results. On the other hand, emergence of ESBL production among Shigella spp. after Salmonella spp. should warn us about the unexpected results of inappropriate antibiotic therapy.