Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity


Saribas G. S. , Erdogan D., Goktas G. , Akyol S., HIRFANOĞLU İ. M. , Gurgen S. G. , ...More

Journal of Obstetrics and Gynaecology, vol.36, no.8, pp.1086-1092, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 8
  • Publication Date: 2016
  • Doi Number: 10.1080/01443615.2016.1209174
  • Title of Journal : Journal of Obstetrics and Gynaecology
  • Page Numbers: pp.1086-1092
  • Keywords: Cisplatin, acetyl l-carnitine, apoptosis, uterine tube, ANTIOXIDANT ENZYMES, RATS, DAMAGE, NEPHROTOXICITY, CHEMOTHERAPY, MECHANISMS, APOPTOSIS, ESTER, LIVER

Abstract

© 2016 Informa UK Limited, trading as Taylor & Francis Group.The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin.