The effect of deferoxamine on brain lipid peroxide levels and Na-K ATPase activity following experimental subarachnoid hemorrhage

Bilgihan A., Türközkan N., Aricioǧlu A., Aykol Ş., ÇEVİK C., Göksel M.

General Pharmacology, cilt.25, sa.3, ss.495-497, 1994 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 3
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1016/0306-3623(94)90204-6
  • Dergi Adı: General Pharmacology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.495-497
  • Anahtar Kelimeler: deferoxamine, lipid peroxidation, Na-K ATPase, Subarachnoid haemorrhage
  • Lokman Hekim Üniversitesi Adresli: Evet

Özet

1. 1. In the present study we have studied the effects of deferoxamine treatment on lipid peroxidation and Na-K ATPase activity after experimental induction of subarachnoid haemorrhage (SAH) in guinea pigs. 2. 2. We assessed the extent of lipid peroxidation by measuring the level of malondialdehyde and Na-K ATPase activity in 3 different groups (sham-operated, SAH, SAH + deferoxamine). 3. 3. There was no significant difference in lipid peroxide content between sham-operated and haemorrhagic animals, but Na-K ATPase activity decreased after SAH. 4. 4. Deferoxamine treatment reduced the malondialdehyde content and induced the recovery of Na-K ATPase activity, exerting a brain protective role against the detrimental effects of the haemorrhage. © 1994.