The effect of deferoxamine on brain lipid peroxide levels and Na-K ATPase activity following experimental subarachnoid hemorrhage

Bilgihan A., Türközkan N., Aricioǧlu A., Aykol Ş., ÇEVİK C., Göksel M.

General Pharmacology, vol.25, no.3, pp.495-497, 1994 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 3
  • Publication Date: 1994
  • Doi Number: 10.1016/0306-3623(94)90204-6
  • Journal Name: General Pharmacology
  • Journal Indexes: Scopus
  • Page Numbers: pp.495-497
  • Keywords: deferoxamine, lipid peroxidation, Na-K ATPase, Subarachnoid haemorrhage
  • Lokman Hekim University Affiliated: Yes

Abstract

1. 1. In the present study we have studied the effects of deferoxamine treatment on lipid peroxidation and Na-K ATPase activity after experimental induction of subarachnoid haemorrhage (SAH) in guinea pigs. 2. 2. We assessed the extent of lipid peroxidation by measuring the level of malondialdehyde and Na-K ATPase activity in 3 different groups (sham-operated, SAH, SAH + deferoxamine). 3. 3. There was no significant difference in lipid peroxide content between sham-operated and haemorrhagic animals, but Na-K ATPase activity decreased after SAH. 4. 4. Deferoxamine treatment reduced the malondialdehyde content and induced the recovery of Na-K ATPase activity, exerting a brain protective role against the detrimental effects of the haemorrhage. © 1994.