The effect of deferoxamine on brain lipid peroxide levels and Na-K ATPase activity following experimental subarachnoid hemorrhage
General Pharmacology, vol.25, no.3, pp.495-497, 1994 (Scopus)
- Publication Type: Article / Article
- Volume: 25 Issue: 3
- Publication Date: 1994
- Doi Number: 10.1016/0306-3623(94)90204-6
- Journal Name: General Pharmacology
- Journal Indexes: Scopus
- Page Numbers: pp.495-497
- Keywords: deferoxamine, lipid peroxidation, Na-K ATPase, Subarachnoid haemorrhage
- Lokman Hekim University Affiliated: Yes
Abstract
1. 1. In the present study we have studied the effects of deferoxamine treatment on lipid peroxidation and Na-K ATPase activity after experimental induction of subarachnoid haemorrhage (SAH) in guinea pigs. 2. 2. We assessed the extent of lipid peroxidation by measuring the level of malondialdehyde and Na-K ATPase activity in 3 different groups (sham-operated, SAH, SAH + deferoxamine). 3. 3. There was no significant difference in lipid peroxide content between sham-operated and haemorrhagic animals, but Na-K ATPase activity decreased after SAH. 4. 4. Deferoxamine treatment reduced the malondialdehyde content and induced the recovery of Na-K ATPase activity, exerting a brain protective role against the detrimental effects of the haemorrhage. © 1994.