Catalytic enantioselective addition of diethylzinc to aldehydes using aziridine based chiral ligands

BULUT A. , Aslan A., Izgü E. Ç. , DOĞAN Ö.

Tetrahedron Asymmetry, vol.18, no.8, pp.1013-1016, 2007 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 8
  • Publication Date: 2007
  • Doi Number: 10.1016/j.tetasy.2007.04.013
  • Title of Journal : Tetrahedron Asymmetry
  • Page Numbers: pp.1013-1016


The readily available ferrocenyl substituted aziridinylmethanol 1 (FAM-1) was used as a chiral catalyst in the diethylzinc addition reaction to aromatic and aliphatic aldehydes to give secondary alcohols in high yields and up to 99% enantiomeric excess at room temperature. The catalyst can be recovered and used without losing its activity. © 2007 Elsevier Ltd. All rights reserved.