Effect of locally administered alendronate on onlay grafts


Tekin U., Ozgul O., Tüz H., KORKUSUZ P., Kocyigit I. D., Atıl F., ...More

Journal of Biomaterials and Tissue Engineering, vol.7, no.8, pp.650-654, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 8
  • Publication Date: 2017
  • Doi Number: 10.1166/jbt.2017.1610
  • Journal Name: Journal of Biomaterials and Tissue Engineering
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.650-654
  • Keywords: Alendronate, Onlay graft, Rabbit model
  • Lokman Hekim University Affiliated: No

Abstract

Objective: The present study compared the effects of local alendronate application on the osteogenesis of autogenous and xenogenous onlay grafts implanted in rabbit mandibles. Material and Methods: 28 New Zealand rabbits were used in this experimental animal study. The animals were randomly divided into 4 groups according to graft material as follows: D1: autogenous graftsaline; D2: 60% autogenous graft-40% alendronate D3: xenogenous bone graft-saline; D4: 60% xenogenous graft-40% alendronate. 3 histologic parameters were evaluated: the ratio of new bone formation to the total defect area, the active osteoblast-lined bone length, and the ratio of osteocytefilled lacunae to total lacunae. At the same time, the grafted zones were evaluated using dual-energy X-ray absorptiometry (DEXA) and the Bone mineral density scores were measured. Results: The present study showed better results for the group receiving alendronate applied to autogenous graft when compared to other groups. Discussion: The administration of alendronate increases the resistance of autogenous graft; it may also enhance new bone formation and increase the viability of xenograft. Further animal studies supported with biomechanical tests are required prior to human studies.