Development of a peptide-containing chewing gum as a sustained release antiplaque antimicrobial delivery system

Faraj J. A., Dorati R., Schoubben A., Worthen D., Selmin F., Capan Y., ...Daha Fazla

AAPS PHARMSCITECH, cilt.8, sa.1, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 1
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1208/pt0801026
  • Dergi Adı: AAPS PHARMSCITECH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: KSL-W, chewing gum, sustained release, cetylpyridinium chloride, antiplaque, antimicrobial, peptide, stability, IN-VITRO, PLAQUE, CHLORHEXIDINE, SUSCEPTIBILITY, RETENTION, KINETICS, XYLITOL, AGENT
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The objective of this study was to characterize the stability of KSL-W, an antimicrobial decapeptide shown to inhibit the growth of oral bacterial strains associated with caries development and plaque formation, and its potential as an antiplaque agent in a chewing gum formulation. KSL-W formulations with or without the commercial antibacterial agent cetylpyridinium chloride (CPC) were prepared. The release of KSL-W from the gums was assessed in vitro using a chewing gum apparatus and in vivo by a chew-out method. A reverse-phase high-performance liquid chromatography method was developed for assaying KSL-W. Raw material stability and temperature and pH effects on the stability of KSL-W solutions and interactions of KSL-W with tooth-like material, hydroxyapatite discs, were investigated.