Bilateral nipple hyperkeratosis treated successfully with topical isotretinoin

Toros P., Önder M., AKCAYOL M. A.

Australasian Journal of Dermatology, vol.40, no.4, pp.220-222, 1999 (Scopus) identifier identifier


A 22-year-old woman presented with bilateral thickening and hyperpigmentation of her nipples since the age of 17 years. There was no history of pregnancy or oral contraceptive pill use. Isotretinoin 0.025% gel was applied twice daily and the lesions disappeared in 4 weeks. After the drug was ceased, recurrence appeared within 4 months. The same therapy, applied for 2 weeks, again cleared the problem.