Simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in tablets by spectrophotometric methods


ERK N., ONUR F.

Analusis, vol.25, no.5, pp.161-163, 1997 (Journal Indexed in SCI Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 5
  • Publication Date: 1997
  • Title of Journal : Analusis
  • Page Numbers: pp.161-163
  • Keywords: absorbancy ratio, benazepril hydrochloride, derivative spectrophotometry, determination, hydrochlorothiazide, pharmaceutical preparation

Abstract

In this study, two new spectrophotometric methods were used for the simultaneous determination of benazepril hydrochloride and hydrochlorothiazide in their binary mixture. In the first method, derivative spectrophotometry, dA/dλ values were measured at 260.7 and 239.8 nm for benazepril hydrochloride and hydrochlorothiazide, respectively, in the first derivative spectra of their combination. The relative standard deviation of the method was found to be 0.77% for benazepril hydrochloride and 0.28% for hydrochlorothiazide. In the second method, the absorbancy ratio method, the quantification of benazepril hydrochloride and hydrochlorothiazide was performed using the absorbances read at 264.0, 258.3 and 236.4 nm in the zero-order spectra of their mixture. The relative standard deviation of the method was found to be 1.26 and 0.36% for benazepril hydrochloride and hydrochlorothiazide, respectively. These two methods have been successfully applied to a tablet containing only these drugs.