Blink reflex abnormalities in chronic alcoholics

NAZLIEL B., Arikan Z., Irkeç C., Karakiliç H.

European Neurology, vol.52, no.2, pp.82-86, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 2
  • Publication Date: 2004
  • Doi Number: 10.1159/000079935
  • Journal Name: European Neurology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.82-86
  • Keywords: blink reflex, chronic alcoholism, central nervous system, peripheral neuropathy, ABSTINENT CHRONIC-ALCOHOLICS, POTENTIALS, LESIONS
  • Lokman Hekim University Affiliated: No


Purpose: The aim of the present study was to evaluate the efficacy of blink reflex as a method for obtaining early diagnosis of cranial nerve involvement in alcoholic patients. Materials and Methods: The study was conducted on 30 male alcoholics with a mean age of 43 years. They had histories of alcohol abuse for at least 6 years (mean: 25). At the time of recording, they had undergone detoxification treatment for a mean of 27 days. Results: R1 (early response), R2Y (second ipsilateral response), and R2C (second contralateral response) latencies in alcoholics were prolonged relative to controls and the differences were statistically significant (p < 0.02, p < 0.001, p < 0.001, respectively). According to the defined criteria, 40% of the patients had abnormal responses, and the most common abnormality was the unilateral prolongation of R1 (13%). Conclusion: Finding abnormal blink reflex responses in alcoholic patients has suggested that blink reflex testing is a useful method for the evaluation of subclinical cranial nerve involvement in alcoholic patients. Blink reflex testing may be useful in detecting early changes and in the follow-up of alcoholic disorder. Copyright © 2004 S. Karger AG, Basel.