Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis

Erbek S. S., Yurtcu E., Erbek S., Atac F. B., Sahin F. I., Cakmak O.

Archives of Otolaryngology - Head and Neck Surgery, vol.133, no.7, pp.705-709, 2007 (SCI-Expanded) identifier identifier


Objective: To investigate the association between nasal polyposis (NP) and single nucleotide polymorphisms of the proinflammatory cytokines IL (interleukin) 1α (the IL1A gene), IL-1β (the IL1B gene), and tumor necrosis factor α (the TNFA gene). Design: Prospective case-control trial. Setting: Tertiary referral center. Patients: Eighty-two patients with NP and 106 healthy volunteers without sinonasal disease. Main Outcome Measures: Genotypes of IL1A (4845G, 4845T), IL1B (-511C, -511T) and TNFA (-238G, -238A and -308G, -308A) were identified by restriction fragment length polymorphism analyses after polymerase chain reaction. Results: The 4845 GT and 4845 TT genotypes of the IL1A gene were associated with NP (P<.05). The frequency of the -511 CC genotype of the IL1B gene was significantly higher in patients with NP than in controls (P=.01). The frequency of the -511 CT genotype of IL1B was significantly higher (P=.01) in the controls than in the patients with NP. The -238 AA genotype of the TNFA gene was higher in the patients with NP than in the controls (P=.05). There was a significantly high risk of susceptibility to NP in patients with the -308 GA genotype of TNFA (P=.001). None of the genotypes of the proinflammatory cytokines were related to sex, the presence of atopy, asthma, or aspirin intolerance (P>.05). Conclusion: The IL1A (4845 GT and 4845 TT), IL1B (-511 CC), and TNFA (-238 AA and -308 GA) genotypes were associated with susceptibility to NP in our study population. ©2007 American Medical Association. All rights reserved.