AIDS (Acquired Immune Deficiency Syndrome) that has been known since 1980's, is a pandemic immunosupressive disease and HIV (Human Immunadeficiency Virus) is identified as the primary cause of this disease. Although, several natural and synthetic compounds were detected to possess anti-HIV activity, only a few of them are licensed for clinical use. One of the approaches on the investigation of the compounds with anti-HIV activity is to investigate the medicinal plants. Numerous compounds isolated from plant sources were shown to possess anti-HIV activity. The current review describes the anti-HIV active natural compounds isolated from various plant sources.