Ischemia-modified albumin as an oxidative stress marker in preeclampsia

Üstün Y., Engin-Üstün Y., Öztürk Ö., ALANBAY İ., Yaman H.

Journal of Maternal-Fetal and Neonatal Medicine, cilt.24, sa.3, ss.418-421, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/14767058.2010.497879
  • Dergi Adı: Journal of Maternal-Fetal and Neonatal Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.418-421
  • Anahtar Kelimeler: Preeclampsia, ischaemia-modified albumin, ACUTE CORONARY SYNDROME, BIOMARKERS, PREGNANCY, ASSOCIATION, OUTCOMES, LIPIDS
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Objective. We examined serum ischaemia-modified albumin (IMA) levels in normal pregnant and preeclamptic women. The primary aim of our study was to assess IMA in women with mild and severe preeclampsia. Methods. Serum ischaemia-modified albumin levels were measured in 18 normotensive and 36 preeclamptic pregnant women by enzyme linked immuno-sorbent assay. Patients were subdivided as having either mild (n = 18) or severe preeclampsia (n = 18). Receiver operating characteristic curve was constructed, and sensitivity and specificity were calculated based on the best cut-off. Results. IMA levels were significantly higher in the mild and severe preeclamptic groups than in the control group. IMA with a cut-off point of 0.31 identified women with preeclampsia with sensitivity 80% and specificity 77.8%. Conclusion. Our study demonstrates that serum levels of IMA correlate with severity of preeclampsia. © 2011 Informa UK, Ltd.