Ischemia-modified albumin as an oxidative stress marker in preeclampsia


Üstün Y., Engin-Üstün Y., Öztürk Ö., ALANBAY İ. , Yaman H.

Journal of Maternal-Fetal and Neonatal Medicine, vol.24, no.3, pp.418-421, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.3109/14767058.2010.497879
  • Title of Journal : Journal of Maternal-Fetal and Neonatal Medicine
  • Page Numbers: pp.418-421
  • Keywords: Preeclampsia, ischaemia-modified albumin, ACUTE CORONARY SYNDROME, BIOMARKERS, PREGNANCY, ASSOCIATION, OUTCOMES, LIPIDS

Abstract

Objective. We examined serum ischaemia-modified albumin (IMA) levels in normal pregnant and preeclamptic women. The primary aim of our study was to assess IMA in women with mild and severe preeclampsia. Methods. Serum ischaemia-modified albumin levels were measured in 18 normotensive and 36 preeclamptic pregnant women by enzyme linked immuno-sorbent assay. Patients were subdivided as having either mild (n = 18) or severe preeclampsia (n = 18). Receiver operating characteristic curve was constructed, and sensitivity and specificity were calculated based on the best cut-off. Results. IMA levels were significantly higher in the mild and severe preeclamptic groups than in the control group. IMA with a cut-off point of 0.31 identified women with preeclampsia with sensitivity 80% and specificity 77.8%. Conclusion. Our study demonstrates that serum levels of IMA correlate with severity of preeclampsia. © 2011 Informa UK, Ltd.