Synthesis and potent antimicrobial activities of some novel retinoidal monocationic benzimidazoles


ALAGÖZ Z., ALP M., KUŞ C., YILDIZ S. , Buyukbingöl E., GÖKER A. H.

Archiv der Pharmazie, vol.339, no.2, pp.74-80, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 339 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1002/ardp.200500168
  • Title of Journal : Archiv der Pharmazie
  • Page Numbers: pp.74-80
  • Keywords: retinoid skeleton, benzimidazole carboxamidines, antibacterial, antifungal activities, FLUCONAZOLE

Abstract

Several 2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1H- benzimidazole-5-carboxamidine analogues were synthesized for their antibacterial and antifungal activities against S. aureus, Methicillin-resistant S. aureus (MRSA), C. albicans, and C. krusei. MIC values of the targeted compounds 43-58 are comparable to those of Fluconazole and Sultamicillin. The most potent compounds, 51 and 53, showed MIC values as 0.78 and 1.56 μg/mL against S. aureus and C. albicans, respectively. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.