Detection of extended spectrum beta-lactamases and antibiotic susceptibilities of Klebsiella pneumoniae strains Klebsiella pneumoniae suşlarinda genişlemiş spektrumlu beta-laktamazlarin ve antibiyotik duyarliliklarinin saptanmasi


TEKEREKOĞLU M. S., Ayan M., OTLU B., Taştekin N., Aǧel H., Durmaz B., ...More

Mikrobiyoloji Bulteni, vol.35, no.2, pp.225-230, 2001 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 2
  • Publication Date: 2001
  • Journal Name: Mikrobiyoloji Bulteni
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.225-230
  • Keywords: Antimicrobial susceptibility, Extended spectrum beta-lactamase, Klebsiella pneumoniae
  • Lokman Hekim University Affiliated: No

Abstract

One hundred Klebsiella pneumoniae strains isolated from various clinical specimens were investigated for the presence of extended spectrum beta-lactamases (ESBL) and the antimicrobial susceptibility patterns. The ESBL production was detected in 44% of strains isolated from inpatients and 14% of strains isolated from outpatients. The antimicrobial susceptibility rates of the total 100 strains and ESBL positive 58 strains were found to be as follows respectively: Cephalotin and cefuroxime 40% and 0%, cefoxitin 78% and 100%, ceftazidime 48% and 20%, cefotaxime 56% and 20%, ceftriaksone 52% and 18%, gentamicin 66% and 40%, amikacin 70% and 65%, ciprofloxacin 88% and 90%, imipenem 80% and 90%, meropenem 100% and 100%, aztreonam 50% and 30%, amoxicillin-clavulonic acid 28% and 10%, and trimethoprimsulphametoxazole 72% and 40 percent. The results indicated that ciprofloxacin, imipenem and meropenem might be used in the therapy of infections due to K. pneumoniae.