Comparative study of dopamine and mannitol effects on renal function during cardiopulmonary bypass by using N-acetyl-β-D-glucosaminidase assay

Dural O., Ozkara A., Celebioglu B., Kanbak N., Ciliv G., AYPAR Ü.

Turkish Journal of Medical Sciences, vol.30, no.5, pp.453-457, 2000 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 5
  • Publication Date: 2000
  • Journal Name: Turkish Journal of Medical Sciences
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.453-457
  • Keywords: Enzyme: N-acetyl-β-D-glucosaminidase, Kidney: function, Pharmacology: dopamine, mannitol, Surgery: cardiopulmonary bypass
  • Lokman Hekim University Affiliated: Yes

Abstract

The protective roles of low-dose dopamine and mannitol infusion in the renal function of patients undergoing cardiovascular surgery were compared in 36 patients by measuring urine N-acetyl-β-D-glucosaminidase activity, serum and urinary creatinine, blood urea nitrogen (BUN) levels and urine output. The patients were randomly selected and received a continuous infusion of dopamine, 3 μg/kg/min (Group I), mannitol, 1 mg/kg/h (Group II), no medication (Group III) before the induction of anaesthesia. Urine N-acetyl-β-D-glucosaminidase activities, serum and urinary creatinine and BUN were determined preoperatively after aortic cross-clamping, and on the first and second postoperative days. Changes in urine N-acetyl-β-D-glucosaminidase activity or serum and urinary creatinine, and BUN levels were not statistically significant (p>0.05) between different groups. Our results revealed that, for the protection of renal function during cardiopulmonary bypass, on comparison, the prophylactic use of 'low-dose' dopamine or mannitol did not display any marked superiority.