Adenosine triphosphate alters the selenite-induced contracture and negative inotropic effect on cardiac muscle contractions

UĞUR M., TURAN B.

Biological Trace Element Research, cilt.79, sa.3, ss.235-245, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 79 Sayı: 3
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1385/bter:79:3:235
  • Dergi Adı: Biological Trace Element Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.235-245
  • Anahtar Kelimeler: sodium selenite, heart, papillary muscle, adenosine triphosphate, oxidant, antioxidant, EXTRACELLULAR ATP, SODIUM SELENITE, RAT, GLUTATHIONE, RECEPTORS
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Selenium is known to play an important role in the physiology of many different cell types and extracellular application of selenite causes cellular dysfunction in many different types of tissues. In a previous study, we have shown that in rat ventricles, sodium selenite (≥1 mM) caused an increase in the resting tension and a decrease in contractile force, in a time-dependent manner. In the present study, we have shown that sodium selenite caused a contracture state both in Langendorff perfused hearts and isolated papillary muscles. We also showed that the application of extracellular ATP (0.1 mM) markedly reduced this detrimental effect of sodium selenite on ventricular contraction in Langendorff perfused hearts and delayed it in isolated papillary muscle preparations. In contrast, isoproterenol (0.1 μM) did not seem to influence this action of sodium selenite in papillary muscle preparations. Possible reasons for this protective effect of ATP to selenite-induced contracture are also discussed.