Medicinal plants used in the treatment of human immunodeficiency virus

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Salehi B., Anil Kumar N. V., Şener B., Sharifi-Rad M., KILIÇ M., Mahady G. B., ...More

International Journal of Molecular Sciences, vol.19, no.5, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 19 Issue: 5
  • Publication Date: 2018
  • Doi Number: 10.3390/ijms19051459
  • Journal Name: International Journal of Molecular Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: acquired immune deficiency syndrome, phytochemistry, pharmacognosy, antiviral, drug discovery, ANTI-HIV ACTIVITY, TYPE-1 REVERSE-TRANSCRIPTASE, INHIBITORY NATURAL-PRODUCTS, TRADITIONAL CHINESE MEDICINE, ACTIVITY IN-VITRO, AIDS AGENTS, ANTIVIRAL ACTIVITY, ESSENTIAL OILS, TRIPTERYGIUM-WILFORDII, AQUEOUS EXTRACTS
  • Lokman Hekim University Affiliated: No

Abstract

© 2018 by the authors. Licensee MDPI, Basel, Switzerland.Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.