Akademik Veri Yönetim Sistemi
Bioprospecting of Natural Pigments in Human Health, Ramamoorthy, Editör, Elsevier Science, Oxford/Amsterdam , Amsterdam, ss.1-20, 2025
The coronavirus disease-19 (COVID-19) pandemic has prompted the investigation of
various therapeutic and preventive approaches. Natural pigments are recognized for
their desired biological activities and have emerged as promising candidates due to
their strong antiinflammatory, antioxidant, and antiviral properties. This chapter focuses
on analyzing the knowledge of natural pigments, including flavonoids, carotenoids,
and betalains, and their possible applications in combating SARS-CoV-2, the virus
that causes COVID-19. Bioactive pigments can influence immune responses, impede
viral replication, and diminish oxidative stress, thus providing a comprehensive strategy
for managing COVID-19. Preclinical studies have so far indicated that flavonoids can
disrupt viral entry and replication, while carotenoids have been shown to enhance mu-
cosal immunity. Moreover, betalains have been recognized for their ability to influence
inflammatory pathways critical in the cytokine storm linked to severe cases of COVID-
19. Although these preclinical and some clinical findings are encouraging, more clinical
validation is essential to assess efficacy, dosage, and safety. This chapter emphasizes
additional clinical research on the therapeutic potential of natural pigments, such as
baicalein, luteolin, myricetin, schaftoside, quercetin, berberin, and curcumin, which
may result in innovative, plant-based interventions for COVID-19, enhancing current
pharmacological methods, and aiding in a holistic public health strategy.