The effect of EGb-761 on morphologic vasospasm in canine basilar artery after subarachnoid hemorrhage

Bayar M., Erdem Y., Ozturk K., Bescalti O., Caydere M., YÜCEL D., ...Daha Fazla

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, cilt.42, sa.3, ss.395-402, 2003 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 3
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1097/00005344-200309000-00011
  • Dergi Adı: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.395-402
  • Anahtar Kelimeler: endothelin, ginkgo biloba, platelet-activating factor antagonist, subarachnoid hemorrhage, vasospasm, PLATELET-ACTIVATING-FACTOR, MONKEY CEREBRAL-ARTERIES, RECEPTOR ANTAGONIST, CEREBROSPINAL-FLUID, GINKGO-BILOBA, FACTOR PAF, ENDOTHELIN, RESPONSES, ATHEROSCLEROSIS, CONSTRICTION
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

This study investigated the effects of Ginkgo biloba extract (EGb-761), an anti-oxidant and platelet-activating factor antagonist, on basilar artery vasospasm in an experimental canine subarachnoid hemorrhage model. Morphometric analyses were performed, and serum and cerebrospinal fluid endothelin-1 levels were measured by radioimmunoassay. Comparisons were made between treated and untreated groups. Twenty-four mongrel dogs were randomly assigned to three groups. The animals in group 1 (n = 8) were not subjected to subarachnoid hemorrhage and received no treatment. In this group, serum and cerebrospinal fluid endothelin-1 levels were measured daily for 8 days. On day 9, the animals were killed and their basilar arteries were excised for histopathological examination. In group 2 (n = 8), subarachnoid hemorrhage was produced using autologous arterial blood, and daily intravenous boluses of saline were administered for the next 8 days. Assessments of endothelin-1 levels and the basilar arteries were performed as described for group 1. In group 3 (n = 8), subarachnoid hemorrhage was produced using autologous arterial blood, and daily intravenous boluses of EGb-761 were administered for 8 days. Endothelin-1 levels and the basilar arteries were assessed as described above. The groups' serum endothelin-1, cerebrospinal fluid endothelin-1, and histopathological findings were compared.