Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: A review of the protective action of melatonin

Gultekin F., Hicyilmaz H.

Archives of Toxicology, cilt.81, sa.10, ss.675-681, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 81 Sayı: 10
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s00204-007-0242-1
  • Dergi Adı: Archives of Toxicology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.675-681
  • Anahtar Kelimeler: melatonin, kidney, free radical, 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid, potassium bromate, OXIDATIVE DNA-DAMAGE, LIPID-PEROXIDATION, FERRIC NITRILOTRIACETATE, POTASSIUM BROMATE, CARBON-TETRACHLORIDE, SODIUM ARSENITE, REACTIVE OXYGEN, NITRIC-OXIDE, VITAMIN-E, GENOTOXICANT 2-NITROPROPANE
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage. © 2007 Springer-Verlag.