Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: A review of the protective action of melatonin

Gultekin F., Hicyilmaz H.

Archives of Toxicology, vol.81, no.10, pp.675-681, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 81 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1007/s00204-007-0242-1
  • Journal Name: Archives of Toxicology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.675-681
  • Keywords: melatonin, kidney, free radical, 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid, potassium bromate, OXIDATIVE DNA-DAMAGE, LIPID-PEROXIDATION, FERRIC NITRILOTRIACETATE, POTASSIUM BROMATE, CARBON-TETRACHLORIDE, SODIUM ARSENITE, REACTIVE OXYGEN, NITRIC-OXIDE, VITAMIN-E, GENOTOXICANT 2-NITROPROPANE
  • Lokman Hekim University Affiliated: No


This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage. © 2007 Springer-Verlag.