The relationship between pregnancy complications and AFP, hCG and unconjuge estriol level in maternal serum Maternal kanda AFP, hCG ve ankonjuge östriol düzeylerinin gebelik komplikasyonlarl ile ilişkisi

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BAKIR F., Çelik H. T., Özdemir Ö., Yildirimkaya M. M.

Turk Hijyen ve Deneysel Biyoloji Dergisi, vol.69, no.4, pp.213-218, 2012 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.5505/turkhijyen.2012.96967
  • Journal Name: Turk Hijyen ve Deneysel Biyoloji Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.213-218
  • Keywords: AFP, HCG, Pregnancy Complications, Unconjuge Estriol
  • Lokman Hekim University Affiliated: No


Objective: The aim of the study was to determine the relationship of pregnancy complications with high low AFP, high HCG and low estriol levels detected in maternal serum in the Ankara regions pregnancy population. Method: 951 patients who had undergone triple test during pregnancy for complication rates at T.C.S.B. Ankara Numune Education and Research Hospital were determined retrospectively. Venous blood samples were taken from each patient, Beta hCG, uE3 and AFP tests performed at Ankara Numune Hospital Biochemistry laboratory by using Immulite One® system which was based competetive immunassay methods. Obtained results reported corrected multiple of the median (median multiple of: MoM) values according to pregnancy weeks by using licenced computer program (Prisca®). The risk calculation was made by Patient's age, race, weight, smoking and diabetes, history of IVF pregnancies and sampling date, using either BPD(biparietal diameter) measurement at ultrasound date or last menstrual period.The patients with high AFP levels (>2 MoM), high HCG levels (>2 MoM), low AFP levels (<0.5 MoM) and low estriol levels (<0.5 MoM) were compared to those with normal levels. The relationship of pregnancy complications and our findings examined. Results: Among 161 patients of whose files were useful for inclusion criteria, nine of 30 patients of whom tripple test results were over the critical limit; 1/250 had undergone amniosynthesis. one of those 30 had Down syndrome. No other Down syndrome detected in other 29 patients who had a risky tripple test result neither with amniosynthesis nor in delivery. There were 16 patients with high AFP (>2 MoM), 48 patients with high HCG (>2 MoM), 21 patients with low AFP (<0.5 MoM) and 11 patients with low estriol levels (<0.5 MoM) among the patients those included to the study group. Conclusion: Down Syndrome Screening tests routinely ordered for pregnancy follow-up in daily practise. In the study, It was concluded that AFP, hCG and unconjuge estriol levels would be valuable for pregnancy complications detection.