p-Trifluoroacetophenone Oxime Ester Derivatives: Synthesis, Antimicrobial and Cytotoxic Evaluation and Molecular Modeling Studies

Bozbey I., SARI S., ŞALVA E., KART D., KARAKURT A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.17, no.2, pp.169-183, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.2174/1570180816666181128112249
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Agricultural & Environmental Science Database, Biotechnology Research Abstracts, EMBASE
  • Page Numbers: pp.169-183
  • Lokman Hekim University Affiliated: No

Abstract

Background: Azole antifungals are among the first-line drugs clinically used for the treatment of systemic candidiasis, a deadly type of fungal infection that threatens mostly immune-compromised and hospitalized patients. Some azole derivatives were also reported to have antiproliferative effects on cancer cells.