Akademik Veri Yönetim Sistemi
Anestezi Dergisi, cilt.20, sa.3, ss.159-167, 2012 (Scopus)
Objective: Acute renal failure following cardiac surgery is a very important cause of morbidity and mortality. The risk has been reduced with a variety of some practises. In this study we investigated the effects of two different methods of using N-Acetylcystein (NAC) during cardiac surgery on renal function. Method: 60 patients with normal renal function were randomly allocated to three groups. Group I had 50 mg kg -1 NAC added to pump priming solution; Group II received 50 mg kg -1 NAC i.v. after induction and had an infusion of 20 mg kg -1 h -1 throughout the operation; Group III was the control group. Demographic and perioperative data, fluid balance, urine output and drainage amounts, haemodynamic data, BUN, creatinine, blood and urine electrolytes, and beta-2 globulin, creatinine clearance and fractional sodium excreation (FeNa) were obtained after induction(T1), before CardioPulmonaryBypass (T2), 30 th minutes of Cardiopulmonary Bypass (T3), after CardioPulmonaryBypass (T4), at the end of the operation (T5), at postoperative 24 th h(T6), and at postoperative 48 th h (T7). Results: There were no difference among the demographic and perioperative data, total amount of fluid given, urine outputs and drainage. Urinary albumine/creatinine ratios inceased in Group III at T2 (p<0.05), in Group I at T3, whereas no significant difference was found in Group II. Creatinine values showed a statistically significant increase postoperatively (T6-T7) in all groups (p<0.05). Beta -2 globuline increased in the control group at T6, whereas in Group I and II at T7. Conclusion: Two different regiments of N-Acetylcystein in coronary artery bypass grafting have some benefical effects, but failed to demonstrate preventive effect after 24 hr operation.