Effects of topically applied prostaglandin f2 alpha on normotensive human eyes

ERKILIÇ K., Ekinciler F., Mirza E., Doğan H., ÇAĞIL N.

Ophthalmic Research, cilt.28, sa.6, ss.351-355, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 6
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1159/000267927
  • Dergi Adı: Ophthalmic Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.351-355
  • Anahtar Kelimeler: prostaglandin F2 alpha, intraocular pressure, glaucoma, topical application, ocular effects, INTRAOCULAR-PRESSURE, ANALOG, GLAUCOMA, DYNAMICS, PHXA41
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

The ocular effects of topical prostaglandin F2 alpha (PGF2α) were studied in normotensive human eyes. PGF2α as tromethamine salt, 100 μg, was applied to one eye of 23 normotensive subjects, intraocular pressure (IOP) and pupil size were measured, objective and subjective findings recorded during the first 24 h. Tonography was performed in 10 subjects. As compared with the baseline, PGF2α caused a significant IOP reduction between 1 and 24 h (p < 0.001), being maximal (4.9 ± 0.5 mm Hg, mean ± SEM, p < 0.001) between 4 and 8 h. As compared with the contralateral control eyes, which received 50 μl of saline, treated eyes exhibited significant IOP reduction between 1 and 24 h (p < 0.001), being maximal (4.2 ± 0.4 mm Hg, mean ± SEM, p < 0.001) at 4 h. PGF2α caused marked conjunctival hyperemia in all eyes. Pupillary diameter was not altered. Aqueous flare and cellular response were not seen. Half of the subjects complained of ocular smarting, mild ocular pain or headache. Total outflow facility did not change (p > 0.05). © 1996 S. Karger AG, Basel.