The relationship between Vitamin D and vasomotor symptoms during the postmenopausal period


Arslanca T., KORKMAZ H., Banu Arslanca S., PEHLİVANOĞLU B., ÖZGAN ÇELİKEL Ö.

Clinical Laboratory, vol.66, no.7, pp.1285-1290, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 7
  • Publication Date: 2020
  • Doi Number: 10.7754/clin.lab.2019.191116
  • Journal Name: Clinical Laboratory
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.1285-1290
  • Keywords: vitamin D, menopause, hot flashes, QUALITY-OF-LIFE, HOT FLASHES, D DEFICIENCY, MENOPAUSE, WOMEN, THERAPY, FLUSHES, TRANSITION
  • Lokman Hekim University Affiliated: No

Abstract

© 2020 Verlag Klinisches Labor GmbH. All rights reserved.Background: During the postmenopausal period, hot flashes are frequent symptoms and might impact quality of life. Vitamin D deficiency is commonly seen in this period. This study aims to assess the association between vitamin D deficiency and hot flashes. Methods: Two hundred ten postmenopausal women were recruited. The participants were divided into two groups: Group 1 consisted of postmenopausal women with hot flashes (n = 104), and Group 2 included the participants without hot flashes (n = 106). Results: The comparison of the two groups concerning vitamin D level showed that 52 patients Group 1 had vitamin 25(OH)D levels below 20 ng/mL, whereas only 25 patients in Group 2 (p < 0.001). After adjusting for age and menopause duration, there was also a significant difference between groups (21.65 vs. 34.17, respectively, p < 0.001). In multiple regression analysis, one unit decrease of vitamin 25(OH)D (1 - 0.941 = 0.059) increased the risk of hot flashes by 5.9%. Conclusions: The decreases of vitamin D levels were significantly associated with hot flashes in postmenopausal women independent of age and menopause duration.