Investigation of the relationship between CE cyst characteristics and genetic diversity of Echinococcus granulosus sensu lato in humans from Turkey


Örsten S., Çiftçi T., Azizova A., Yüce G., Uysal A., İmamoǧlu Ç., ...More

Parasitology, vol.147, no.14, pp.1712-1717, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 147 Issue: 14
  • Publication Date: 2020
  • Doi Number: 10.1017/s0031182020001535
  • Journal Name: Parasitology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1712-1717
  • Keywords: Echinococcus granulosus sensu lato, genetic diversity, human cystic echinococcosis, parasitic cyst characteristics
  • Lokman Hekim University Affiliated: No

Abstract

Cystic echinococcosis (CE) is one of the most common zoonotic diseases worldwide, particularly in rural areas. This study aimed at the identification of the genotype/species belonging to Echinococcus granulosus sensu lato (s.l.) specimens in retrieved percutaneously from the human host and to investigate their relationship with cyst characteristics. The genetic identification of cyst material was performed by mt-CO1 gene polymerase chain reaction, and confirmed via sequencing. A total of 110 CE cysts were identified as E. granulosus s.l. In detail, 104 belonged to E. granulosus sensu stricto (G1 and G3) and six isolates were in the E. canadensis cluster (G6/7). All clusters were tested for the relationship between demographics, cyst features and genetic diversity. The relationship between genetic variation and certain clinical characteristics such as cyst volume and location were statistically significant for G6/7 cluster. Further studies are required with a larger sample set to investigate the relationship between the genetic variability of E. granulosus s.l. and cyst features.