Comparative morphometric analysis of thyrocytes in invasive part and intranodular part of tumor in minimally invasive follicular carcinoma of thyroid

Yildiz F. R., UMUDUM H.

Nobel Medicus, vol.6, no.3, pp.24-27, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 3
  • Publication Date: 2010
  • Journal Name: Nobel Medicus
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.24-27
  • Keywords: Thyroid, minimally invasive, follicular carcinoma, morphometry, COMPUTERIZED NUCLEAR MORPHOMETRY, CLASSIFICATION, ANEUPLOIDY, MUTATIONS, PATHOLOGY, NEOPLASMS, LESIONS, CANCER
  • Lokman Hekim University Affiliated: Yes

Abstract

• Objective: Current study aims to compare the morphometric differrences of capsule invading and non-invading thyrocytes in microinvasive follicular carcinomas of thyroid (MIFC). • Material and Method: Materials of this retrospective study came from archival pathological materials cases of MIFC. Neoplastic thyrocytes in capsule invading and non invading areas were marked on hematoxylin and eosin stained sections. Nuclear morphometric features of thyrocytes from invading areas and non invading areas were obtained and compared. • Results: A total of 13 pathological materials from 9 patients were selected. Capsule invading thyrocytes had significantly larger nuclear area and perimeter than those of non invasive thyrocytes in MIFC (p<0.005). • Conclusion: Nuclei of capsule invading thyrocytes were larger than non invading thyrocytes. This difference has not been reported previously. This finding supports the proposal that follicular adenomas of thyroid may be the precursor lesion of MIFC in some cases.