Evaluation of cochlear involvement by distortion product otoacoustic emission in Behçet's disease

Dagli M., Eryilmaz A., Tanrikulu S., Aydin A., Gonul M., Gul U., ...More

Auris Nasus Larynx, vol.35, no.3, pp.333-337, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.anl.2007.09.003
  • Journal Name: Auris Nasus Larynx
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.333-337
  • Keywords: Behcet's disease, cochlear hearing loss, DPOAE (distortion product otoacoustic emission) testing, IMMUNE-COMPLEXES, DISORDERS
  • Lokman Hekim University Affiliated: No

Abstract

Objective: The aim of this study was to investigate cochlear involvement in patients with Behçet's disease. Materials and methods: Twenty-six Behçet's disease patients (52 ears) and 24 sex and age-matched healthy control subjects (48 ears) were included in the study. Pure-tone audiometry at frequencies 250, 500, 1000, 2000, 4000, 6000 Hz, immittance measures including tympanometry and acoustic reflex testing and DPOAE (distortion product otoacoustic emission) testing were performed in the patients and controls. Results: A sensorineural hearing loss was found in eight patients (30.7%) as it was bilateral in five and unilateral in three patients. Although no typical audiometric configuration was found, one patient had a flat type audiogram, and the others had a high frequency hearing loss. The DPOAE responses of the patients and controls were significantly different in all frequencies (p < 0.05). Conclusion: These results indicate that cochlea is affected by damage of outer hair cells in Behçet's disease. © 2007 Elsevier Ireland Ltd. All rights reserved.