Severe rhabdomyolysis due to malignant hyperthermia during renal transplantation procedure can cause delayed graft function

Caglar K., Orhan M. E., Gulec B., YAVUZ İ., Yenicesu M., Guzeldemir E., ...More

American Journal of Nephrology, vol.22, no.1, pp.81-83, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1159/000046678
  • Journal Name: American Journal of Nephrology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.81-83
  • Keywords: malignant hyperthermia, renal transplantation, rhabdomyolysis, CONTRACTURE
  • Lokman Hekim University Affiliated: No


A case of rhabdomyolysis from malignant hyperthermia occurred during renal transplantation surgery is presented. After the completion of vascular and uretherovesical anostomosis, the patient's heart rate began to rise, sweatiness was observed and body temperature increased to 41°C. Additionally, metabolic and respiratory acidosis and hyperkalemia were detected. Serum creatine kinase and lactic dehydrogenase levels were increased significantly. After external cooling and the administration of dantrolene sodium, body temperature and heart rate were decreased. During this period; furosemide, mannitol and sodium bicarbonate were given. Three hours after the completion of surgery, urine output was begun and urine myoglobin was found to be positive. Renal function improved gradually and serum creatinine level decreased to 1.6 mg/dl on the 14th postoperative day. Malignant hyperthermia can lead to severe rhabdomyolysis and delayed graft function in renal transplant recipients. Early diagnosis and intervention is crucial for protecting renal function. Copyright © 2002 S. Karger AG, Basel.