Isolation of the lignan 6-methoxypodophyllotoxin from Linum boissieri and biosynthesis of lignans in this species
Pharmaceutical Biology, cilt.43, sa.9, ss.737-739, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 43 Sayı: 9
- Basım Tarihi: 2005
- Doi Numarası: 10.1080/13880200500406313
- Dergi Adı: Pharmaceutical Biology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.737-739
- Anahtar Kelimeler: lignan, Linum boissieri, 6-methoxypodophyllotoxin, CELL, PODOPHYLLOTOXIN, CULTURES
- Lokman Hekim Üniversitesi Adresli: Hayır
Özet
We were able to establish a suspension culture of Linum boissieri that produces 6-methoxypodophyllotoxin (6MPT). As a first step to gain insight into the lignan biosynthesis in L. boissieri cell cultures, we were able to measure phenylalanine ammonia-lyase (PAL) activity in raw protein extracts. PAL is a key enzyme in the early part of the general phenylpropanoid pathway, leading (beside others) to the precursors for lignan biosynthesis. © 2005 Taylor & Francis Ltd.