Isolation of the lignan 6-methoxypodophyllotoxin from Linum boissieri and biosynthesis of lignans in this species

KONUKLUGİL B., Fuss E., Alfermann W.

Pharmaceutical Biology, cilt.43, sa.9, ss.737-739, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 9
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/13880200500406313
  • Dergi Adı: Pharmaceutical Biology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.737-739
  • Anahtar Kelimeler: lignan, Linum boissieri, 6-methoxypodophyllotoxin, CELL, PODOPHYLLOTOXIN, CULTURES
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

We were able to establish a suspension culture of Linum boissieri that produces 6-methoxypodophyllotoxin (6MPT). As a first step to gain insight into the lignan biosynthesis in L. boissieri cell cultures, we were able to measure phenylalanine ammonia-lyase (PAL) activity in raw protein extracts. PAL is a key enzyme in the early part of the general phenylpropanoid pathway, leading (beside others) to the precursors for lignan biosynthesis. © 2005 Taylor & Francis Ltd.