Leser-Trélat sign: Does it really exist?

Turan E., YEŞİLOVA Y., Yurt N., Koçarslan S.

Acta Dermatovenerologica Croatica, vol.21, no.2, pp.128-130, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 2
  • Publication Date: 2013
  • Journal Name: Acta Dermatovenerologica Croatica
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.128-130
  • Keywords: Leser-Trelat sign, seborrheic keratoses, paraneoplastic syndrome, SEBORRHEIC KERATOSES, INTERNAL MALIGNANCIES, ACANTHOSIS NIGRICANS, ADENOCARCINOMA, LUNG
  • Lokman Hekim University Affiliated: No


Leser-Trélat sign is a rare cutaneous disorder that manifests with sudden emergence of seborrheic keratoses and increase in their numbers and size within weeks or months. Its concurrence with many types of malignancies, especially adenocarcinoma and lymphoma, has been reported in the literature. In this case report, a patient having Leser-Trélat sign, without any detected malignancy in spite of detailed examination and 18 months of follow up, is presented. Current literature is reviewed in relation to the debate whether Leser-Trélat is a paraneoplastic syndrome or not.