Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species

GÖKER A. H., KUŞ C., Boykin D. W., YILDIZ S., ALTANLAR N.

Bioorganic and Medicinal Chemistry, cilt.10, sa.8, ss.2589-2596, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 8
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0968-0896(02)00103-7
  • Dergi Adı: Bioorganic and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2589-2596
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids (35, 38), ethyl-5-carboxylate (36), -5-carboxamides (37, 39),-5-carboxaldehyde (42), -5-chloro (40), -5-trifluoromethyl (41), and -5-carbonitriles (44-53, 55-67), -6-carbonitrile (54) were prepared and evaluated in vitro against Candida species. The cyano substituted compounds 53, 57, 58 and 61 exhibited the greatest activity with MIC values of 3.12 μg/mL, values similar to that of fluconazole. © 2002 Elsevier Science Ltd. All rights reserved.