Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species

GÖKER, ALİ; KUŞ, CANAN; Boykin, David; YILDIZ, SULHİYE; ALTANLAR, NURTEN

doi:10.1016/s0968-0896(02)00103-7

Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species

GÖKER A. H., KUŞ C., Boykin D. W., YILDIZ S., ALTANLAR N.

Bioorganic and Medicinal Chemistry, vol.10, no.8, pp.2589-2596, 2002 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 10 Issue: 8
Publication Date: 2002
Doi Number: 10.1016/s0968-0896(02)00103-7
Journal Name: Bioorganic and Medicinal Chemistry
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.2589-2596
Lokman Hekim University Affiliated: No

Abstract

New 2-substituted-phenyl-1H-benzimidazole-5-carboxylic acids (35, 38), ethyl-5-carboxylate (36), -5-carboxamides (37, 39),-5-carboxaldehyde (42), -5-chloro (40), -5-trifluoromethyl (41), and -5-carbonitriles (44-53, 55-67), -6-carbonitrile (54) were prepared and evaluated in vitro against Candida species. The cyano substituted compounds 53, 57, 58 and 61 exhibited the greatest activity with MIC values of 3.12 μg/mL, values similar to that of fluconazole. © 2002 Elsevier Science Ltd. All rights reserved.