Spinal cord protection with the use of prostacyclin during aortic occlusion

Katircioglu S., Saritas Z., YÜCEL D., Bayazit M., Tasdemir O., Bayazit K.

JOURNAL OF SURGICAL RESEARCH, cilt.65, sa.1, ss.77-81, 1996 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 65 Sayı: 1
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1006/jsre.1996.0346
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.77-81
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

This study was planned to investigate if prostacyclin (PGI(2)) would reduce spinal cord injury following aortic occlusion. Twelve dogs underwent 90 min of aortic occlusion. Six dogs received PGI(2) and the remaining animals did not. PGI(2) was administered at a dose of 25 ng/kg/min during occlusion of the aorta. There were five paraplegic animals in the control group and one in the PGI(2) group 72 hr after aortic occlusion. Neurological recovery was better in the PGI(2) group than in the control group (P < 0.05). Malondialdehyde level was 3.55 +/- 0.58 nmole/ml in the PGI(2) group and 6.35 +/- 1.27 nmole/ml in the control group 60 min after aortic cross-clamp removal (P < 0.05). At the same time interval, protein thiol groups were 629 +/- 50 mu mole/L in the PGI(2) group and 376 +/- 69 mu mole/L in the control group (P < 0.05). Distal arterial pressure and central venous pressure were 15 +/- 4 and 12 +/- 3 mm Hg in the control group and 33 +/- 5 and 7 +/- 1.6 mm Hg in the PGI(2) group, respectively (P < 0.05). In this study exogenously administered PGI(2) protected the spinal cord from the hazardous effects of aortic occlusion lasting 90 min. (C) 1996 Academic Press, Inc.