Serum irisin level can predict the severity of coronary artery disease in patients with stable angina


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Efe T. H., AÇAR B., Ertem A. G., Yayla K. G., Algül E., Yayla Ç., ...Daha Fazla

Korean Circulation Journal, cilt.47, sa.1, ss.44-49, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4070/kcj.2016.0079
  • Dergi Adı: Korean Circulation Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.44-49
  • Anahtar Kelimeler: Coronary artery disease, Atherosclerosis, Irisin, CIRCULATING IRISIN, INSULIN-RESISTANCE, MYOCARDIAL-INFARCTION, MESSENGER-RNA, WEIGHT-LOSS, ASSOCIATION, OBESITY, ATHEROSCLEROSIS, INTERVENTION, MYOKINES
  • Lokman Hekim Üniversitesi Adresli: Hayır

Özet

Background and Objectives: The recently discovered myokine irisin has a proposed role in adipose tissue metabolism. The aim of this study was to evaluate the relationship between serum irisin level and the coronary artery severity in patients with stable coronary artery disease (CAD). Subjects and Methods: Sixty-three patients who underwent coronary angiography (CA) diagnosed with stable CAD and twenty-six patients with normal coronary artery (NCA) were enrolled in the study. Stable CAD patients were divided into two groups as high synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score (≥23) and lower SYNTAX score (<23). Serum irisin level measurement was carried out using human irisin colorimetric enzyme-linked immunosorbent assay (ELISA) commercial kit (AG-45A-0046EK-KI01, Adipogen, San Diego, CA, USA) as recommended by the manufacturer's protocol. Results: The patients with stable CAD with a higher SYNTAX score (score ≥23) had significantly lower serum irisin levels (127.91±55.38 ng/mL), as compared the patients with a low SYNTAX score (score <23) (224.69±92.99 ng/mL) and control group (299.54±123.20 ng/mL). Irisin levels showed significant differences between all groups (p<0.001). Conclusion: Serum irisin level is an independent predictor of coronary artery severity in patients with stable CAD. (Korean Circ J 2017;47(1)44-49).